ICEECE2012 Poster Presentations Thyroid (non-cancer) (188 abstracts)
Adaptation of the hypothalamo-pituitary-thyroid axis to pubertal development and exposure to acute and chronic physical stresses
A. Younus 1 , A. Naseem 1 , S. Aslam 2 , M. Irfan 1 , F. Tahir 3 , M. Qayyum 1 , R. Mansoor 4 , S. Murtaza 3 & S. Rizvi 1,
1PMAS Arid Agriculture University, Rawalpindi, Pakistan; 2Government College university, Lahore, Pakistan; 3National Institute of Health, Islamabad, Pakistan; 4Rawalpindi Medical College, Rawalpindi, Pakistan; 5Pakistan Science Foundation, Islamabad, Pakistan.
The hypothalamo-pituitary-thyroid axis undergoes adaptive changes in response to increased energy expenditure at puberty, a process called thyroidarche. Furthermore, the secretion of thyroid hormones (THs) is influenced by various kinds of acute and chronic stresses. Amongst others, persistent and severe physical stress may affect the secretion of THs. The present study investigates changes in the secretion of thyrotropin releasing hormone (TSH), trioiodothyronine (T3) and tetraiodothyronine (T4) during puberty and the effect of acute and chronic physical stresses on the secretion of TSH, T3 and T4. Blood samples were obtained from non-working school/college going and working boys between the age of 10 and 20 years (n=594), plasma concentrations of TSH, T3, T4 and cortisol were determined using specific ELISA. Data were analyzed using Student’s t-test, ANOVA and Pearson correlation. The secretion of TSH peaked at 14th year and was maintained until 18th year in non-working boys. In working boys, TSH peaked at 11 years and was maintained by 18th year. The concentrations of T3 increased progressively until 17 years. In working boys, T3 peaked at 10, 16 and 20 years. T4 concentrations increased significantly at 11, 15 and 17 years. In working boys, T4 peaked at 10, 13 and 18 years. In non-working boys, the concentrations of TSH and T3 were lower at early puberty and higher at mid and late puberty, whereas concentrations of T4 were higher at early and mid puberty. In both groups, a positive correlation was seen between plasma TSH and T3 concentrations and linear growth velocity during early and mid puberty. The concentrations of cortisol were significantly higher in working boys of all age groups. In conclusion, the present study demonstrates that the secretion of TSH and T3 increases at puberty and that acute stress increases TSH and T3 concentrations whereas chronic stress reduces them.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector
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Endocrine Abstracts
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