Endocrine Abstracts

The clear cell renal carcinoma (CCRC) is the best known primary site of metastatic thyroid. The thyroid metastases can be the first sign of a kidney tumor, or appear long after the nephrectomy, in which case can may mistakenly diagnose a thyroid cancer early.

Goal: Examine ways of presentation, diagnosis and treatment of patients with thyroid metastases from clear cell renal carcinoma (TMCCRC).

Method: From January 1, 1985 to July 31, 2011 the diagnosis of TMCCRC was given to 9 patients at the Thyroid Center of Reggio Emilia. For the present study were enrolled eight because in one patient the clinical data were incompletes. In each patient we describe clinical manifestation, ultrasound description and anatomopathological aspects.

Results: Eight patients were enrolled: two women (25%) and six men (75%). The first diagnostic approach to TMCCRC was sporadic in three patients (37.5%), in two patients (25%) was by find increase in volume of the anterior region of the neck, in a patient (12.5%) for research of thyroid metastasis after nephrectomy for CCRC and in another two patient (25%) was the cytological reassessment after nephrectomy for a CCRC: both patients were previously cytological class T2. The TMCCRC were found in the right lobe in five patients (62.5%) and in the left lobe in three patients (28.57%).

Conclusions: The mode of presentation, the type of response, the clinical course and sonographic features of TMCCRC are heterogeneous. There is the possibility of confusing the TMCCRC with follicular neoplasm essentially in the absence of recognized previous CCRC. RECOMMENDATIONS. The finding of a nodule (s) of thyroid gland in patients with a history of CCRC must lead to the cytological analysis regardless of the ultrasound description. At the time of diagnosis of CCRC should evaluate the morphology of the thyroid.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector