ICEECE2012 Poster Presentations Thyroid cancer (108 abstracts)
Is thyroid cancer recurrence risk increased after transplantation?
H. Tisset 1 , N. Kamar 2 , I. Faugeron 3 , C. Pouteil-Noble 1 , M. Klein 4 , L. Frimat 4 , G. Mourad 5 , D. Drui 6 , C. Do Cao 7 , M. Vanthygem 7 , C. Noel 7 , L. Leenhardt 8 , P. Rodien 9 , F. Bonichon 10 , E. Morelon 1 , S. Leboulleux 11 , C. Bournaud 1 , A. Kelly 12 , P. Niccoli 13 , M. Schlumberger 11 & F. Borson-Chazot 1
1University hospital Lyon, Lyon, France; 2University hospital Toulouse, Toulouse, France; 3University hospital Saint Louis, Paris, France; 4University hospital Nancy, Nancy, France; 5University hospital Montpellier, Montpellier, France; 6University hospital Nantes, Nantes, France; 7University hospital Lille, Lille, France; 8University hospital Paris La Pitié, Paris, France; 9University hospital Angers, Angers, France; 10Institut Bergonie, Bordeaux, France; 11Institut Gustave Roussy, Villejuif, France; 12Centre Jean perrin, Clermont-Ferrand, France; 13CHU La Timone, Marseille, France.
Context: An increased mortality by cancer is reported in grafted patients.
Objective: This multicentric study aimed to investigate whether the prognosis of thyroid cancer was modified by transplantation
Results: Sixty nine patients (35 M/34 F; median age 41 years) with a history of both thyroid cancer and transplantation were recruited via specialized networks (TUTHYREF and DIVAT). Evolution and outcome were retrospectively analyzed after a median follow-up of 13 years. Ninety one per cent were papillary and 9% of the follicular type.
Thyroid cancer had been diagnosed before transplantation in 33/69 patients from whom 36.4% had a high risk cancer. At the time of the graft, 31 were in remission, four of them after a recurrence. Two patients recurred after transplantation and a remission was obtained after a complementary treatment. In a young female patient who presented before transplantation lung metastases, a 2 years complete remission was observed after bilateral lung transplantation for cystic fibrosis.
In 36 patients thyroid cancer was diagnosed after transplantation from whom 47% were at high risk of recurrence. After a median follow-up of 14 years, 31 patients were in remission, four had persistent disease, one deceased from progression of thyroid cancer. In nine cases, a second transplantation was performed 6.5 years after thyroid cancer diagnosis. During follow-up, a remission after two local recurrences occurred in one patient, persistent disease remained stable in one and there was no recurrence in the seven other patients.
As a whole, 90% of patients were in remission at the time of the study. Seven per cent of patients experienced a recurrence and all of them were N1.
Conclusion: The prognosis of thyroid cancer does not seem to be hampered by transplantation. This suggests that thyroid cancer should not be considered as a contra indication to transplantation, even in patients with persistent disease.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more