Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2012) 29 P1767

University of Messina, Messina, Italy.


The prevalence of differentiated thyroid carcinoma (DTC) in lingual thyroid (LT) and thyroglossal duct cysts (TDC) is around 1%. Nowadays, almost 200 cases of DTC were reported in TDC and <60 cases in LT. Here we report four cases of neoplasia in LT (1/4) and TDC (3/4) in a consecutive series of 950 DTC patients (0.4%).

Case 1: D.F. 63 year-old woman with thyroid follicular carcinoma in ectopic gland located at her tongue’s basis. March 2009: the lesion, infiltrating surrounding tissues, presented insular-like areas (T3N1Mx). July 2009 and 2010: two radiometabolic treatment (cumulative dose of 224 mCi of 131I) with no evidence of local/distant metastases and undetectable serum thyroglobulin (Tg), following the last radioiodine administration.

Case 2: B.B. 37 year-old woman with TDC. October 2001: exeresis of a thyroid papillary carcinoma (PC) in TDC infiltrating soft local tissues (T3NxMx). December 2001: Total thyroidectomy (tTx) with histologic finding of benign adenomatous goiter. 2002–2008: five radiometabolic treatment (cumulative dose of 500 mCi of 131I) due to iodine uptaking lung metastases. September 2009: persistence of elevated Tg levels (56.1 ng/ml) following recombinant human TSH stimulation. Proposal of further radiometabolic treatments refused.

Case 3: B.S. 42 year-old man. November 2001: PC of thyroglossal duct infiltrating the surrounding fibro-adipose tissue with lymphatic and intravascular diffusion. March 2002: tTx with evidence of two foci of PC (T3bN0Mx). July 2002: 100 mCi of 131I, Tg undetectable and WBS negative.

Case 4: D.B. 21 year-old woman with a PC follicular variant in TDC. July 2010: tTx with histologic evidence of benign macrofollicular goiter.

Conclusions: The higher prevalence of DTC (also in form of aggressive variants) in dysembrogenetic than in eutopic thyroid tissue (0.4 vs 0.004%) argues in favor of a close monitoring of all the dysembriogenetic thyroid lesions.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Volume 29

15th International & 14th European Congress of Endocrinology

European Society of Endocrinology 

Browse other volumes

Article tools

My recent searches

No recent searches.

My recently viewed abstracts