Endocrine Abstracts

Symptom of tall is manifestation of many endocrine and genetic diseases. Their early detection is necessary for timely therapy, for improvement of disease state and prognosis for a disease. 47 XYY syndrome is one of frequent occurrence diseases that are accompanied with primary tall. Materials and methods. Patient L., 12 years old, was under our observation. Chief complaint – tall height. Intracranial hypertension, delay in speech development and gross motor delay were registered on the first year of life.

Results: Children’s weight – 97.3 kg, height – 195 sm. Rate of growth for current year made up 12 sm. Physical growth and development – high and disharmonious, body mass index – 25.5 kg/m². Sexual formula of Tanner: P3, Ax1, gonads in marsupium 12 ml. Predict final height of bone age (14 years old 6 months) constituted 204 sm. This data exceed significant index of genetic height (188.5 sm). Indices of biochemical blood assay, glucose loading had normal values. Levels of thyroid-stimulating hormone (TSH), free thyroxin, follicle-stimulating hormone, interstitial cell-stimulating hormone, chondrotropic hormone, prolactin and of cortisol were within the established norms. Values of insulin-like growth factor-1 (761.0 ng/ml, n 249 – 642 ng/ml) and of testosterone (18.9 ng/ml, n 2.8 – 8.0 ng/ml) had high normative indices. In the process of karyotyping chromosome pathology (karyotype 47 XYY) was established in child. Consultation of neurologist: asthenia, pseudoneurotic tics.

Conclusions: i) It was mad the exclusion: 47 XYY syndrome. ii) Treatment: testosterone enanthate at doses 500 mg, 2 weeks, in the course 6 months. iii) At this moment present patient do not require treatment (bone age>13.5 years old, treatment is prescribed at the age of 13–13.5 years old, after effect of exogenous androgens on precipitation of closing of bone growth plate is insignificant). It is necessary supervision of endocrinologist, control of rate of height, of rate of sexual maturation.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.