Endocrine Abstracts

Aim: The aim of our study was to evaluate the effectiveness of the body mass (BM) decreasing program in pubertal children with alimentary obesity during the year of observation.

Materials and methods: Anthropometric changes in body mass index (BMI) and waist circumflex (WC) were analyzed every 1, 3, 6 and 12 months in 100 obese pubertal children (boys/girls =50/50) with different treatment methods: the 1st group – only reducing diet (b/g=30/30), the 2nd – combination with sport (12/11) and the 3rd – combined with metformin hydrochloride (9/8).

Results: There were no differences in initial BMI and WC between the 1st (30.3±3.9 kg/m² and 92.1±10.8 cm) and 2nd groups (29.8±3.7 kg/m² and 89.6±11.7 cm; P>0.05). The 3rd group’s primary BMI and WC surpassed the same parameters in the 1st and 2nd groups (35.5±7.4 kg/m² and 102.7±15.8 cm), that was in keeping with abdominal obesity (P=0.001 and P=0.007; P=0.01 and P=0.02). There were no BMI changes in the 1st group during follow-up period (P>0.05). Gradual BMI decreasing was registered relating to initial ones starting from the 1st month of therapy (29.61±3.29; 29.18±3.53; 28.53±3.45; 27.23±3.63 kg/m², P=0.003). BMI reduction trend was observed every 3, 6 and 12 month (P>0.05) in the 3rd group. There were no differences between WC rates during the follow-up time regardless of treatment types. However WC decreasing tendency was noted in 3rd group (103.83±17.65; 103.11±17.13; 102.03±16.52; 99.86±15.97 cm).

Conclusions: Reducing nutrition combined with vigorous physical activity is enough for BM reducing in patient with uncomplicated obesity. Dietary intake combined with metformin hydrochloride should be recommended in children with abdominal and morbid adiposity.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.