ICEECE2012 Poster Presentations Female Reproduction (99 abstracts)
Significance of obesity in the genesis of metabolic syndrome in women with polycystic ovary syndrome
J. Bjekic-Macut 1 , D. Macut 2 , I. Bozic 2 , D. Vojnovic-Milutinovic 3 , O. Stanojlovic 4 , B. Popovic 2 , T. Bogavac 2 , M. Petakov 2 , S. Ognjanovic 2 , T. Isailovic 2 , V. Elezovic 2 , M. Civcic 2 , S. Erceg 2 , G. Matic 3 & S. Damjanovic 2
1Clinical-Hospital Center ‘Bezanijska kosa’, Belgrade, Serbia; 2Clinic for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 3Institute for Biologic Investigation ‘Sinisa Stankovic‘, University of Belgrade, Belgrade, Serbia; 4Medical Faculty, Institute for Physiology, University of Belgrade, Belgrade, Serbia.
Introduction: Metabolic disturbances that are common in polycystic ovary syndrome (PCOS), represent a risk factor for cardiovascular disease. The aim of this study was to define contribution of obesity for the development of dyslipidemia and insulin resistance in PCOS.
Methods: PCOS was diagnosed using ESHRE/ASRM criteria. We evaluated 158 women with PCOS who were divided into two subgroups according to body mass index (BMI) cut off value 25 kg/m2: non-obese PCOS (n=93; 20.65±2.0 kg/m2; 24.9±4.6 years) and overweight/obese PCOS (n=65; 31.0±4.6 kg/m2; 26.7±6.7 years). Controls group consisted of 30 healthy, non-obese (19.9±2.1 kg/m2, 27.5±5.3 years). In all subjects fasting blood samples were collected in follicular phase of menstrual cycle for determination of glucose, insulin, total cholesterol (TC), LDL, HDL, triglycerides, apolipoproteins (Apo) A1, A2, B and E, Lp(a), C-reactive protein (CRP), testosterone and SHBG. Blood pressure (BP), waist circumference (WC), free androgen index (FAI), homeostatic model (HOMA index), and ratios TC/HDL, LDL/HDL, triglycerides/HDL, ApoB/ApoA1 were also determined.
Results: In comparison to non-obese PCOS, obese PCOS had significantly higher levels of TC, LDL, triglycerides, ApoB, ApoE, CRP, HOMA, FAI, TC/HDL, LDL/HDL, triglycerides/HDL, ApoB/ApoA1, and significantly lower levels of HDL and ApoA1 (P<0.001). After adjustment for age, non-obese PCOS had borderline higher ApoB/ApoA1 than Controls (P=0.051). In PCOS group BMI significantly correlated with TC, HDL, triglycerides, HOMA, ApoB, and CRP (P<0.001). There were no significant correlations between FAI and metabolic indices. HOMA significantly correlated only with BMI (P<0.001).
Conclusion: Proaterogenic lipid profile and insulin resistance are metabolic consequences of PCOS. Obesity significantly worsens metabolic profile in women with PCOS.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more