Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2012) 29 P969

ICEECE2012 Poster Presentations Female Reproduction (99 abstracts)

Relation of hyperandrogenism and metabolic derangements in women with polycystic ovary syndrome

T. Bogavac 1 , D. Macut 1 , I. Bozic 1 , J. Bjekic-Macut 2 , B. Popovic 1 , M. Petakov 1 , S. Ognjanovic 1 , T. Isailovic 1 , V. Elezovic 1 & S. Damjanovic 1


1Clinic for Endocrinology, Diabetes and Metabolic Diseases, Cinical Center of Serbia, Faculty of Medicine, University of Belgrade, Belgrade, Serbia; 2Clinical-Hospital Center ‘Bezanijska kosa’, Belgrade, Serbia.


Introduction: Polycystic ovary syndrome (PCOS) is associated with a higher risk for development of metabolic syndrome. In this study, we evaluated the degree of metabolic disorders in women with different PCOS phenotypes.

Methods: We analyzed 162 women with PCOS (BMI: 24.9±6.1 kg/m2, age:25.6±5.6 years) diagnosed on the basis of ESHRE/ASRM criteria, and 39 women without PCOS who comprised the control group (CG; BMI: 21.4±4.1 kg/m2, age: 28.4±5.4 years). Women with PCOS were divided into three subgroups according to the presence of hyperandrogenism (HA): A – with biochemical HA (n=97), B – with clinical HA (n=28), and C – without clinical or biochemical HA (n=37). In all subjects basal blood samples were collected in follicular phase of menstrual cycle for determination of glucose, insulin, total cholesterol (TC), HDL, LDL, triglycerides, apolipoproteins (Apo) A1, A2, B and E, lipoprotein (a), C-reactive protein (CRP), testosterone and SHBG. We used the standard formula to calculate HOMA, FAI, and lipid ratios TC/HDL, LDL/HDL, triglycerides/HDL, ApoB/ApoA1. PCOS and CG differed (P<0.01) in age and body mass index (BMI), and the calculations were done with the correction for these parameters.

Results: In PCOS subgroups, significant difference was found in concentrations of Apo A1 (P=0.017) due to the difference between subgroups A and C (1.49±0.24 vs 1.72±0.32 g/l). PCOS subgroup A had significantly higher (P<0.001) FAI index compared to subgroup B and C (A: 14.4±11.0%, B: 4.3±1.0%, C: 4.3±1.4%). FAI and ApoA1 had significant positive correlation (ρ=−0.32, P<0.01).

Conclusion: Women with hyperandrogenic PCOS phenotype have a significantly lower value of favorable ApoA1 in comparison to the PCOS phenotype without hyperandrogenism.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Volume 29

15th International & 14th European Congress of Endocrinology

European Society of Endocrinology 

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