Epicardial adipose tissue thickness in patients with polycystic ovary syndrome

A. Aydogdu; G. Uckaya; I. Tasci; O. Baysan; S. Tapan; B. Bugan; M. Serdar; S. Aydogdu; H. Akbulut; U. Aydogan; A. Sonmez; O. Azal

EAT has been linked to the presence and severity of cardiovascular disease. EAT has been linked to the presence and severity of cardiovascular disease. We searched if the patients with PCOS have increased EATT, or not.

Total of 41 subjects with PCOS and 46 age and body mass index (BMI) matched healthy controls were enrolled. EAT was measured by echocardiography.

EATT and HOMA-IR score were significantly higher (P=0.0001 for both) while plasma adiponectin concentration was significantly lower (P=0.048) in PCOS patients. EATT correlated positively with total cholesterol, triglyceride, insulin, LH, LH/ FSH, HOMA-IR score and negatively with SHBG (P<0.05 for all), whereas it displayed no correlation to plasma adiponectin level (P=0.924). Triglyceride level and LH/FSH ratio were the significant determinants of EATT in logistic regression analysis (P=0.0001, P=0.024 respectively).

Table 1 Anthropometrics and basic laboratory results of patients with PCOS and healthy controls.
Parameter	PCOS subjects (n=41)	Controls (n=46)	P value
Age (year)	20.9±3.2	21.3±3.0	0.159
BMI (kg/m²)	23.6±4.3	22.4±2.6	0.138
Waist-to-hip ratio	0.7±0.0.4	0.7±0.04	0.923
Fasting plasma glucose (mg/dl)	87.3±8.1	82.2±6.4	0.002
Total cholesterol (mg/dl)	162.1±38.7	159.7±32.6	0.947
HDL-cholesterol (mg/dl)	50.0±11.7	53.8±9.7	0.102
LDL- cholesterol (mg/dl)	90.7±28.5	93.0±27.7	0.710
Triglyceride (mg/dl)	105.7±71.7	64.1±21.2	0.002
LH (mIU/ml)	7.4±4.8	5.3±3.1	0.016
FSH (mIU/ml)	4.9±1.9	5.5±1.6	0.151
Total testosterone (ng/dl)	63.1±28.8	43.4±15.6	0.0001
SHBG (nmol/l)	32.9±16.8	59.8±26.3	0.001
DHEA-S (μg/dl)	345.0±135.0	283.5±95.1	0.018
LH/FSH	1.6±1.0	1.0±0.6	0.002
HOMA-IR value	2.2±1.2	1.3±0.5	0.0001
Insulin (mIU/ml)	10.3±5.1	6.5±2.2	0.0001
Adiponectin (μg/ml)	10.0±3.7	12.5±6.1	0.048
EAT thickness (mm)	4.4±1.5	3.2±1.1	0.0001
BMI, body mass index; HDL, high density lipoprotein; LDL, low high density lipoprotein; SHBG, sex hormone binding globulin; HOMA-IR, homeostasis model assessment of insulin resistance; EAT, epicardial adipose tissue.

EATT is increased in patients with PCOS and may be an effective tool to determine those PCOS subjects at the risk of cardiovascular events.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.

Endocrine Abstracts

P963