Endocrine Abstracts

We are living in the electronic era and day to day exposed by estrogenic disruptors such as Bisphenol-A (BPA). Electronic gadgets such as cellular phones, CDs, DVDs, RFIDs even baby feeding bottles are made with composition of BPA and their huge application are matter of debate in present. The chronic exposures of BPA have become a major health concern. In this study we assessed the neurobehavioral alterations caused by BPA in the rats. We examined the neurobehavioral changes in Albino Wister rats of (190±20) g body weight. Two groups of rats, control and BPA treated (4 mg/kg body weight in corn oil), were used to find the effects of BPA. Neuro-behavioural studies were carried out as per plan after the last dose of treatment. A set of five rats randomly selected from each treatment group was used to assess spontaneous locomotor activity 24 h after the last dose of treatment. The same set of rats was used to measure grip strength, 1 h after the spontaneous locomotor activity test. Locomotor activity parameters were assessed in control and BPA treated rats at age of 90 and 120 days. Exposure to BPA in rats caused a decrease in total distance travelled (42%), stereotypic time (52%), time moving (38%), rearing (44%) and an increase in resting time (17%) as compared to rats in the control group. Finally we observed that BPA exposure (4 mg/kg b.wt.) cause neurobehaviour alterations in rats. The chronic exposure of BPA may cause neurotoxicity and that can result mental problems like weakness, memory, cognitive and locomotor dysfunction etc.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This work was supported, however funding details unavailable.