Endocrine Abstracts

Objective: To evaluate associations between adiposity trajectories over time and insulin sensitivity and glucose deterioration in a Chinese twin cohort.

Research Design and Methods: This study focused on 341 males and 292 females who aged 20–50 years old at baseline and had physical, clinical examinations and oral glucose tolerance test(OGTT) at two time points with an average of 6 years apart. Body mass index (BMI), waist circumference (WC), percent body fat (PBF), and percent trunk fat (PTF) trajectories were classified into 5 track groups based on age- and gender-specific tertiles at each visit. We calculated the odds of the insulin sensitivity index(0.120) (ISI(0.120)) or glycemic deterioration at follow-up among 5 defined trajectories (tertile baseline to tertile follow-up) using generalized estimate Default (GEE). Additionally, we applied structural equation models to examine genetic and environmental influences on adiposity, adiposity change over time(ACO), ISI(0.120), and the inter-relationships.

Results: Participants with adiposity (BMI, WC, PBF and PTF) stable in the highest tertile or shifting to the highest tertile tended to have the lowest ISI(0.120) at follow-up or experience glycemic deterioration. Genetic factors exerted the major influence on adiposity, but environmental factors unique to each twin contributed more strongly to ISI and ACO. Correlations between adiposity/ACO and insulin sensitivity were mainly due to environmental influences.

Conclusion: When adiposity stays or becomes high, insulin sensitivity falls and risk of glycemic deterioration rises. Additionally, we found that genetic factors exerted the major influence on adiposity, while environmental factors played the principal role for ACO and insulin sensitivity.

Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.

Funding: This work was supported, however funding details unavailable.