Endocrine Abstracts

Introduction: PCOS is characterized by insulin resistance and an increased risk of type 2 diabetes.Objective: To study the association between birth weight and risk of polycystic ovary syndrome (PCOS) in adult life in Danish women born 1973–1991.Methods: Female offspring born in Denmark during 1973–1991 of Danish mothers (n=523, 757) were included and followed for a total of 4, 739, 547 person-years at risk. Inform...

Primary Ovarian Insufficiency (POI) is an ovarian defect characterized by the premature depletion of ovarian follicles before 40 years and represents one major cause of female infertility. POI is a heterogeneous disease but, despite its idiopathic origin in most of patients, there is a strong genetic evidence, in particular for X chromosome-linked defects. BMP15 gene maps to Xp11.2 within a Turner locus critical for ovarian function and mutations in this gene have been found i...

Introduction: Weight loss is a key initial treatment strategy in obese women with polycistic ovary syndrome (PCOS) and improves insulin sensitivity and metabolic risk factors. In some women with PCOS it may reduce hyperandrogenism and restore menstrual function, ovulation and fertility. The aim of this study was to reveal clinical predictors of menstrual response to weight loss in overweight women with PCOS.Design: overweight unovulatory women with PCOS ...

The aim of this epidemiologic study, performed in a wide population of high-school students in Northern Italy, was to obtain an unbiased estimate of the prevalence of hyperandrogenic states in adolescents and young females.2052 female students, aged 15–19 years, were consecutively contacted. 939/2052 (45.8%) refused to participate in the study, but 431 of the 939 non-participants (45.9%) agreed to fill out a brief questionnaire aimed to broadly asse...

Polycystic ovary syndrome (PCOS) is a triad of insulin resistance, hyperandrogenism and anovulation. PCOS is associated with increased adrenocortical drive, which may have adverse metabolic consequences. Here we analysed the relationship of urinary androgen and glucocorticoid metabolite excretion with insulin resistance in a large PCOS cohort.We compared results from 127 PCOS patients (Rotterdam criteria) with 100 BMI-matched controls. All subjects under...

Background: Sex-steroid feedback regulates gonadotropin (LH and FSH) secretion. Kisspeptin, a novel hypothalamic neuropeptide, stimulates gonadotropin secretion by stimulating GnRH secretion, and has been shown in animal models to play a central role in mediating sex steroid feedback.Hypothesis: As estrogen feedback occurs at both the hypothalamus and the pituitary in women, we hypothesized that the stimulatory effect of kisspeptin-10 would be dependent ...