Endocrine Abstracts

The melanocortin receptor (MCR) family consists of five G protein-coupled receptors (MC1R-MC5R) with diverse physiological roles. MC1R controls pigmentation, MC2R is a critical component of the hypothalamic-pituitary-adrenal axis, whilst MC3R and MC4R have a vital role in energy homeostasis and MC5R is involved in exocrine function.The melanocortin receptor accessory proteins, MRAP and its paralogue MRAP2, are small single-pass transmembrane proteins tha...