Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2012) 28 P295

SFEBES2012 Poster Presentations Reproduction (23 abstracts)

Total and free testosterone concentrations are strongly influenced by age and central obesity in men with type 1 and type 2 diabetes but correlate weakly with symptoms of androgen deficiency and diabetes-related quality of life

Moushmi Biswas 1 , David Hampton 2 & Aled Rees 3


1Dept of Medicine, Royal Gwent Hospital, Newport, United Kingdom; 2Biochemistry, Royal Gwent Hospital, Newport, United Kingdom; 3Centre for Diabetes and Endocrine Sciences, University Hospital of Wales, Cardiff, United Kingdom.


Background: Testosterone levels are commonly lowered in men with diabetes but it is unclear whether these impact upon symptoms of androgen deficiency and diabetes-related quality of life.

Objective: To investigate the relationship between testosterone levels, symptoms of androgen deficiency, erectile function and diabetes-related quality of life in men with type 1 and type 2 diabetes. Design: Cross-sectional study of 115 men with type 2 diabetes, 93 men with type 1 diabetes and 121 healthy controls.

Results: Forty-five and sixty-one percent of men with type 2 diabetes had low total and calculated free testosterone levels, respectively. Total testosterone levels were not lowered in men with type 1 diabetes but 32% had low calculated free testosterone. After adjustment for age and waist circumference, only calculated free testosterone in men with type 2 diabetes (−0.037 nmol/l, 95% CI −0.075 to −0.0003, P=0.048) remained lowered compared with controls. Calculated free testosterone correlated weakly with Androgen Deficiency in the Aging Male (r=−0.26, 95% CI −0.42 to −0.08, P=0.006), International Index of Erectile Function (r= 0.19, 95% CI 0.01 to 0.37, P=0.042) and Audit of Diabetes Dependent Quality of Life (r= 0.21, 95% CI 0.03 to 0.38, P=0.022) scores in men with type 2, but not type 1 diabetes. Age exerted the predominant effect on erectile function in both groups, in a model incorporating age, testosterone level and complications.

Conclusions: Testosterone levels are strongly affected by age and central obesity in men with type 1 and type 2 diabetes but correlate weakly with symptoms of androgen deficiency and erectile function. Testosterone levels do not appear to be a major determinant of quality of life in patients with diabetes.

Declaration of interest: There is no conflict of interest that could be perceived as prejudicing the impartiality of the research reported.

Funding: No specific grant from any funding agency in the public, commercial or not-for-profit sector.

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