ea0028pl5 | Society for Endocrinology Jubilee Medal Lecture | SFEBES2012
Sheppard Michael
Acromegaly is associated with increased morbidity and premature mortality (predominantly due to vascular disease), but these effects can be reduced if GH levels are controlled (<2.5 µg/l) and IGF-1 levels are normalized. Confounding pituitary hormone deficiencies, particularly ACTH deficiency (with higher doses of hydrocortisone replacement) may have a detrimental effect on outcome in patients with pituitary disease. Pituitary radiotherapy is a further factor that has...