ECE2011 Poster Presentations Diabetes (epidemiology, pathophysiology) (32 abstracts)
Diagnostic criteria for glucose homeostasis abnormalities in obese patients: are there any differences?
J Mesquita 1, , P Rodrigues 1, , C Nogueira 1 , S Belo 1 , C Esteves 1 , M J Matos 1, , A Varela 1, , P Freitas 1, , Joana Queirós 1 , Flora Correia 1, , Bruno Oliveira 3 , Manuel Ferreira de Almeida 1 , João Tiago Guimarães 1, , José Luís Medina 1, & Davide Carvalho 1,
1Hospital São João, Porto, Portugal; 2Faculty of Medicine, Porto University, Porto, Portugal; 3Faculty of Nutrition and Food Science, Porto University, Porto, Portugal.
Introduction: The course of type 2 diabetes mellitus (DM) is insidious and, before its development, other glucose homeostasis abnormalities can be detected: impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and elevation of HbA1c.
Aims: To compare the prevalence of glucose homeostasis abnormalities in obese patients, using diagnostic criteria of American Diabetes Association (ADA) 2009, ADA 2010 and International Diabetes Federation (IDF) 2005.
Methods: Patients were 39.9 (10.6) years old and had a body mass index (BMI) of 45.5 (5.4) kg/m2. Mean fasting glycaemia was 99.1 (20.1) mg/dl, mean glycaemia at 120′ of OGTT was 147.5 (52.0) mg/dl and mean A1c was 5.8 (0.8)%. Considering ADA 2009 criteria, prevalence of isolated IFG was 8.4%, isolated IGT was 17.5%, IFG associated with IGT was 4.9% and DM was 20.3%. When the criteria A1c≥6.5% was added to the previous criteria, the percentage of DM rose to 23.1%. On the other hand, when considering each criteria of DM alone, prevalence of DM was 10.5% by fasting plasma glucose≥126 mg/dl, 18.9% by plasma glucose at 120′ of OGTT≥200 mg/dl and 14.0% by A1c≥6.5%. Finally, using the criteria of IDF 2005, prevalence of IFG decreased to 2.1% and IFG combined with IGT decreased to 3.5%.
Conclusions: OGTT alone was the best method for diagnosing diabetes in obese patients. Criterion A1c≥6.5% increased the prevalence of diagnosed DM.
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Endocrine Abstracts
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