Endocrine Abstracts

DM is a major cause of blindness, cardio-vascular risk the highest in the diabetics. More than 40% of all trauma-unrelated lower extremity amputations are performed because of diabetic foot syndrome (DFS) and lower extremity gangrene, 35–40% of all deaths due to uremia fall to the diabetics.

Aim: To study DM late complications prevalence and risk factors contributing to their progression.

Materials and methods: A total of 1000 and 1141 patients with type 2 diabetes mellitus, urban and rural residents, respectively, underwent general clinical examination; arterial pressure, carbohydrate and lipid metabolism parameters were measured. A special questionnaire was filled up for each patient.

Results: The study established higher DM late complications prevalence in urban diabetics as compared with those rural (P<0.001). Incidence of macroangiopathies of lower extremity vessels, DFS and myocardial infarction (MI) was found higher in males than the one in females, while ischaemic heart disease (IHD) prevalence was registered higher in females regardless of region. Increase in incidence of DM late complications with the disease duration was found in both regions (P<0.001). Prevalence of macroangiopathies, diabetic polyneuropathy and DFS upon the decompensated disease was the highest both among urban and rural residents. The smokers had higher prevalence of diabetic retinopathy, macroangiopathies of lower extremity vessels, MI and IHD regardless of region. Age contributes to progression of DM late complications too.

Conclusions: DM late complications incidence is higher in the urban diabetics, than in the countrymen. Sex, age, disease duration, compensation stage and bad habits are found the risk factors of DM late complications progression.

Keywords: epidemiology, diabetes mellitus, late complications, urban and rural populations, risk factors.