Endocrine Abstracts

Research objective: To estimate interrelation of carbohydrate exchange compensation with indicators of blood lipids.

Methods: Four hundred and seven patients suffering from diabetis of 1 and 2 types at the age of 47.20 (35.63^25th–57.42^75th) have been examined. The disease experience – 10.90 (6.40^25th –18.46^75th) years. All the examined patients have been divided into 3 groups. In the first group are patients with the glycated hemoglobin level <7.5%; in the second – 7.6–10.5%; in the third – more than 10.5%. Average age and the diabetes experience didn’t differ authentically among patients of the three groups. Among the given patients blood lipids have been defined. The range of reference values for triglycerids (TG) has made 0.20–1.89 mmol/l; lipids of high density (HDL) – 1.04–1.55 mmol/l; lipids of low density (LDL) – 0.10–4.00 mmol/l; very low density (VLDL) – 0.10–0.70 mmol/l.

Results: It is proved that at a diabetes the levels of triglycerids among the examined of the first group have made 1.17 (0.47^25th–1.63^75th) mmol/l and were authentically lower in comparison with patients of the third group 1.79 (1.05^25th–2.48^75th) mmol/l (U=3333.00; P=0.0002). HDL and VLDL levels among patients of 1 group have made 2.83 (1.76^25th –3.20^75th) mmol/l and 0.55 (0.34^25th–0.78^75th) mmol/l, accordingly. HDL and VLDL levels were authentically lower against indicators of patients of group 3 (3.45 (2.5^25th–4.8^75th) mmol/l and 0.81 0.81 (0.49^25th–1.12^75th) mmol/l) (U=7609.50; P=0.01 and U=7315.00; P=0.03, accordingly). At carrying out of the correlation analysis direct authentic correlation between glycated hemoglobin levels and TG (r_S=0.20 is determined; P=0.000001); glycated hemoglobin levels and VLDL (r_S=0.17; P=0.0007).

Conclusions: At a diabetes, as aggravation of carbohydrate metabolism disorder, metabolic lipid imbalance progress: increase in TG HDL and VLDL levels.