Endocrine Abstracts

Aim: To define the frequency of diabetic retinopathy course in type1 diabetes mellitus (T1DM) patients with and depression; to study the relation between depression and diabetic retinopathy severity.

Materials and methods: One hundred and thirty-three T1DM patients aged 40.27±12.17 years (56 males and 77 females) without exacerbation of chronic and acute inflammatory diseases and verified mental disorders were included into the study. The duration of T1DM before the moment of inclusion into the study was 12.16±3.65 years. The hospital scale of anxiety and depression was used for detection of depression. The depression was estimated at indicators of 8-21 scores. Statistical processing of the material was performed using STATISTICA 6.0.

Results: For definition of frequency of development of diabetic retinopathy in patients with depression the study group was divided into subgroups: patients without diabetic retinopathy, patients with non-proliferative diabetic retinopathy, and patients with diabetic preproliferative and proliferative retinopathy. In T1DM patients with depression the frequency of diabetic preproliferative and proliferative retinopathy was 55.5% and was significantly higher than in patients without depression (44.5% (x²=5.60; P=0.018). There were no differences among subgroups of patients with non-proliferative retinopathy and diabetic preproliferative and proliferative retinopathy (x²=2.81; P=0.094). For analysis of the frequency of laser coagulation execution there were singled out the following subgroups: T1DM patients with diabetic retinopathy without laser coagulation and with laser coagulation. In patients with depression the frequency of execution of retina laser coagulation is 70% that is higher to compare patients without depression (30%) (x²=3.90; P=0.048).

Conclusions: In T1DM and depression patients the frequency of diabetic retinopathy is higher to compare patients without depression.