ECE2011 Poster Presentations Cardiovascular endocrinology and lipid metabolism (34 abstracts)
Prevalence of androgen deficiency in males with metabolic syndrome: relation between hormonal and metabolic parameters
Antonio Becerra 1, , Gilberto Perez-Lopez 1 , Miriam Menacho 3 , Jose M Rodriguez-Molina 1, , M Jesus Lucio 1 , Nuria Asenjo 1 & Rosa Villar 5
1Gender Unit, Department of Endocrinology, Hospital Universitario Ramon y Cajal, Madrid, Spain; 2University of Alcala, Madrid, Spain; 3Department of Biochemistry, Hospital Universitario Ramon y Cajal, Madrid, Spain; 4Autonomous University, Madrid, Spain; 5Department of Endocrinology, Hospital Universitario de Fuenlabrada, Madrid, Spain.
Androgen deficiency in the aging male has become an actual topic due to the aging population and finding from different studies that shown a progressive decline of serum levels of age-related testosterone. These levels have been inversely related with markers of metabolic syndrome and cardiovascular disease.
The aim of this observational study was to investigate the relation of endogenous testosterone and other sex hormones with different components of metabolic syndrome, as defined by the National Cholesterol Education Program (NCEP), in a Spanish middle-aged and elderly male population.
We studied 73 consecutive men with metabolic syndrome (criteria NCEP), aged between 40 and 70 years. The body weight, waist circumference and arterial pressure were measured, and fasting serum levels of glucose, insulin, lipid profile, total testosterone (TT), SHBG, dehydroepiandrosterone sulfate (DHEA-S) and estradiol were determined. The insulin resistance was calculated by use of the HOMA index.
Our male population present an evident androgenic deficit (TT <230 ng/dl) in 9/73 cases (12.3%) and a partial androgenic deficit (TT 230–345 ng/dl) in 34/73 cases (46.6%). We find an inversely significant correlation of values of TT with those HOMA index (r=−0.293, P<0.05) and those waist circumference (r=−0.312, P<0.05).
In conclusion, our findings show that patients with metabolic syndrome could present a relatively high prevalence of hypogonadism, so this abnormality must be investigated in this population. The decrease in androgen concentrations in men could be relationed with insulin resistance, and in consequence with the development of diabetes mellitus and cardiovascular disease.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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