Endocrine Abstracts

Study: Retrospective, cohort.

Material and methods: A. Hashimoto thyroiditis (HT) diagnosis: i) antithyroperoxydase antibodies (ATPO) criteria; cut-off >34 IU/ml. ii) If ATPO=normal (N), HT was considered only antithyroglobuline antibodies (ATG) were >50 IU/ml (↑) and ultrasound was pattern 1 (pseudonodular, intense hypoechogenic, inhomogeneous – Peretianu, Endocrine Abstracts, 2007, 14, P340; 2008, 16, P772; 2009, 20, P79).

B. Patients: 1000 patients. HT: women: 950, men 5%.

Results: A. At the diagnostic moment (DiMo). i) Function: euthyroid (EUT): 460 (46%), hypothyroid (HOT): 397 (39%), hyperthyroid: 143 (15%) – from these: 95 (66%) associated certainly (TRAB⁺) Graves–Basedow disease (GBD). ii) ATPO: average: 620, S.D.: 1060. min: 1, max: 13 000. In 7 (0.7%), ATPO high, even no thyroid was detected. 28 with ATPO=N. iii) 26 (33%) HT with TRAB⁺ were EUT/HOT. iv) Amiodarone association: 14 (1.4%): 6 EUT, 4 HOT, 2 HIT.

B. Follow-up. i) Function: a. 15 (3.25%) with EUT became HOT after 0.2(!)-5 years (average=2.16, S.D.=1.72). b. 100% HOT remained HOT. c. HIT without treatment at 3 years become EUT in only 3, HOT in only 1. ii) ATPO: a. Evolutive type: undulatory: 118 (45%), decreasing: 34 (34%), increasing: 23 (56%). b. Linear correlation with thyroid hormone/ TSH: none; r=0.5/0.17, P=0.9 (NS).

Discussion: i) Ultrasound thyroid patterns. ii) ATPO histogramme by intervals. iii) Most common association in HT was GBD (see also Poiană, Endocrine Abstracts, 2008, 16, P7822).

Conclusions: i) HT presented more as EUT than HOT. ii) Only 2.5% EUT-HT become HOT, during first 5 years. iii) For searching new HOT, TSH at 3 months. iv) ATPO is not correlated to thyroid (function and morphology). v) No EUT-HT after 5 years modified function. vi) Amiodarone did not affect thyroid function. vii) HT-GBD is more difficult to control nonradically than GBD-no HT; if medical treatment, >3 years.