Endocrine Abstracts

Aim of research: To determine uric acid level in blood serum and incidents of hyperuricemia in postmenopausal women and their relation with body mass index (BMI).

Object of research: Patients of clinic by the physiology and pathology of bone and joint disease department and Ukrainian medical-scientific center of osteoporosis: postmenopausal women (n=134). They were divided in the following groups depending on BMI: I group (BMI=20.0–24.9) – normal weight, II group (BMI=25.0–29.9) – overweight, III group (BMI=30.0–34.9) – class I obesity, IV group – class II obesity (BMI=35.0–39.9). Average age of examined patients was 64.3±0.8 years.

Methods of research: Retrospective analysis of patients’ case histories. Patients were hospitalized to the clinic of physiology and pathology of bone and joint diseases, Institute of Gerontology AMS of Ukraine. Uric acid level in blood plasma was determined by uricase-peroxidase method, statistic analysis – by Statistica 6.0.

Results: Uric acid level among women during postmenopausal period depends on body mass index. The higher level of uric acid were found in patients with obesity of II class. In the I group it was 285.0±13.4; in II group – 285.2±13.5; in III group – 281.7±8.3, in IV group – 329.7±17.7. Incidence of hyperuricemia among women in the I group was 12.9%, in II group – 23.5%; in III group – 18.6%, in IV group – 39.0% (differences between I and IV groups was significantly (P<0,05)).

Conclusions: It was determined that uric acid level among women during postmenopausal period depending on body mass index. The higher level of uric acid and incidence of hyperuricemia were found in women with obesity of II class in comparison with women who have normal body mass index.