ECE2011 Poster Presentations Obesity (47 abstracts)
Effects of natural dietary antioxidants on insulin and IGF1 in obese patients with insulin resistance
A Mancini 1 , M Magini 2 , R Festa 4 , S Raimondo 1 , A Silvestrini 3 , A Pontecorvi 1 , E Meucci 3 & GE Martorana 2,
1Department of Internal Medicine, Catholic University of the Sacred Heart, Rome, Italy; 2Department of Laboratory Medicine, Dietetic Service, Rome, Italy; 3Institute of Biochemistry and Clinical Biochemistry, Catholic University of the Sacred Heart, Rome, Italy; 4Department of Molecular Pathology, Marche Politechnic University, Ancona, Italy.
Oxidative stress (OS) could play an important role in metabolic syndrome (MS)-related manifestations contributing to insulin resistance (IR). The reciprocal influences between OS and IR are not clear. We investigated the effects of dietary antioxidants on IR, studying 24 obese (7 males and 17 females, 27–66 years), with IR evaluated by HOMA index, during treatment with metformin, comparing 2 dietary treatments: hypocaloric diet (group A, n=16) or a diet enriched with natural antioxidants (group B, n=8). A personalized program, with mean caloric intake of 1500 Kcal, 25% proteins, low glycemic index CHO and a calculated antioxidant intake of 800–1000 mg/daily, derived from fruit and vegetables, was administered to group B. OGTT and evaluation of total, LDL and HDL-cholesterol, triglycerides, uric acid, albumin and IGF1 were performed before and after a 3-months treatment. Total antioxidant capacity was determined by H2O2-metmyoglobin system which, interacting with the chromogen ABTS, generates a radical with a latency time (LAG) proportional to antioxidant content. Despite a similar significant BMI decrease, we found a significant decrease of insulin AUC and a significant increase in IGF1 in group B, together with a trend in increasing LAG values in the same group.
| BMI (kg/mq) | Insulin AUC (mcUI/ml per 120’) | IGF1 (ng/ml) | LAG (s) | |
| Group A pre | 37.6±1.3 | 14912.6±2008.2 | 155.1±14.2 | 63.2±3.1 |
| Group A post | 36.1±1.3* | 13789.5±1594.9 | 163.1±10.4 | 66.3±5.3 |
| Group B pre | 35.2±2.0 | 19179.0±3848.4 | 109.7±12.7 | 56.2±5.1 |
| Group B post | 32.2±1.4* | 11362.9±705.8* | 140.7±23.0* | 60.6±5.5 |
| Mean±S.E.M., P<0.05, versus pretreatment values. | ||||
These data suggest that dietary antioxidants ameliorate insulin-sensitivity in obese insulin-resistant subjects enhancing the effect of insulin-sensitizing drugs, although the molecular mechanisms remain still to be elucidated. The reciprocal pattern of hormone response (insulin and IGF1) is similar to that observed after bariatric surgery-induced weight loss, suggesting an increase in GH sensitivity linked with an insulin decrease.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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