ECE2011 Poster Presentations Pituitary (111 abstracts)
Hyperprolactinemia is a risk factor for radiological vertebral fractures in post-menopausal women
G Mazziotti 1, , T Mancini 3 , M Mormando 4 , E De Menis 5 , A Bianchi 4 , M Doga 1 , L De Marinis 4 & A Giustina 1
1University of Brescia, Montichiari-Brescia, Italy; 2Azienda Ospedaliera ‘Carlo Poma’, Mantova, Italy; 3General Hospital, San Marino, Italy; 4Catholic University of Rome, Rome, Italy; 5General Hospital, Montebelluna-Treviso, Italy.
Hyperprolactinemia may cause bone loss in pre-menopausal women and men. Data on fractures are scanty and it is still unclear which is the skeletal impact of hyperprolactinemia in post-menopausal women. The aim of this study was to evaluate the prevalence of vertebral fractures in post-menopausal women with hyperprolactinemia.
Forty post-menopausal women (median age 57 years, range: 47–81) with prolactin (PRL)-secreting adenoma and 119 control post-menopausal women (median age 58, range: 48–74) with normal PRL values were studied by morphometric assessment of vertebral fractures and DXA measurement of bone mineral density.
Vertebral fractures were shown in 22 women with PRL-secreting adenoma (55.0%) and in 38 controls (31.9%; P=0.009). The difference in vertebral fractures between women with prolactinoma and controls was significant either in presence of osteoporosis (P=0.009) or osteopenia (P=0.01), whereas this difference was not significant with normal BMD T-scores. Among PRL-secreting adenoma, fractured patients were older (P=0.01) and had lower BMD (P=0.002), longer duration of disease (P<0.001) and higher (P=0.04) serum PRL values vs. patients who did not fracture. Fractures occurred more frequently (P=0.003) in patients with untreated hyperprolactinemia versus patients treated with cabergoline whose frequency of vertebral fractures was comparable to that observed in control women. In multivariate analysis duration of disease maintained a significant correlation with vertebral fractures even after correction for age, treatment with cabergoline, BMD and serum PRL values.
Hyperprolactinemia is associated with high prevalence of vertebral fractures in post-menopausal women and its pharmacological treatment should always be considered in this clinical setting.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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