Endocrine Abstracts

Aim of the current glucocorticoid treatment strategies in patients with classic types of CAH due to 21 hydroxylase deficiency is to replace the lack of cortisol (substitution) and, secondly, to suppress excess adrenal androgen production by restoring the negative feedback on ACTH release (suppression).In adolescence, besides adequate substitution, achieving normal puberty and menstrual cycle, preventing hyperandrogenism (hirsutism) and prevention of the ...

In the UK 1 in 500 children will develop cancer in childhood. Survival from childhood cancer has more than doubled since the 1960s. Survivorship is increasingly on the agenda and the National Cancer Survivorship Initiative has been launched in the UK.During adolescence the endocrinologist is faced with four challenges in managing childhood cancer survivors:-1. Managing the immediate endocrine consequences of cancer therapy, in part...

The management of type 1 diabetes (T1D) in puberty and adolescence is characterized by special challenges related to the dramatic hormonal, emotional and social changes in the teenage years. It is a period of transition from physical immaturity to maturity and from parental dependency to independence. The daily application of insulin, necessity of frequent selfmonitoring of blood glucose and awareness of diabetic diet represent additional burdens for teenagers with diabetes. I...