ECE2011 Poster Presentations Pituitary (111 abstracts)
Patients previously treated for nonfunctioning pituitary macroadenomas have disturbed sleep characteristics, circadian movement rhythm, and subjective sleep quality
S D Joustra , N R Biermasz , E Donga , A M Pereira , N Van Duinen , M Van Dijk , A A Van der Klaauw , E P M Corssmit , Gert Jan Lammers , Klass Van Kralingen , J G Van Dijk & J A Romijn
Leiden University Medical Centre, Leiden, The Netherlands.
Context and objective: Fatigue and excessive sleepiness have been reported after treatment of nonfunctioning pituitary macroadenomas (NFMA). Because these complaints may be caused by disturbed nocturnal sleep, we evaluated objective sleep characteristics in patients treated for NFMA.
Design: Controlled cross-sectional study.
Subjects and methods: We studied 17 patients (8 women, mean age 54 years), in remission of NFMA during long-term follow-up (8 years, range 1–18 years) after surgery (n=17) and additional radiotherapy (n=5) without co-morbidity except for hypopituitarism and 17 controls matched for age, gender, and BMI. Sleep was assessed by nocturnal polysomnography, sleep and diurnal movement patterns by actigraphy, and quality of life and subjective sleep characteristics by questionnaires.
Results: Compared to controls, patients had reduced sleep efficiency (P=0.008), less REM-sleep (17.1 vs 25.4%, P<0.001), 10% more N1 sleep (P=0.001) and more awakenings, in the absence of excessive apnea or periodic limb movements. Actigraphy revealed a longer sleep duration and profound disturbances in diurnal movement patterns, with more awakenings at night and less activity during the day. Patients scored higher on fatigue, and reported impaired quality of life.
Conclusion: Patients previously treated for NFMA suffer from decreased subjective sleep quality, disturbed distribution of sleep stages and disturbed circadian movement rhythm. These observations indicate that altered sleep characteristics may be a factor contributing to impaired quality of life and increased fatigue in patients treated for non-functioning macroadenomas.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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