ECE2010 Symposia Non-classical responses to hormones (4 abstracts)
Rapid androgen action in epithelial and stromal cells
Gabriella Castoria , Antimo Migliaccio , Pia Giovannelli , Tiziana Giraldi & Ferdinando Auricchio
Department of General Pathology, II University of Naples, Naples, Italy.
Androgen stimulation triggers rapid activation of signaling pathways in target cells. The initial event is a rapid interaction of classical androgen receptor (AR) with Src. Activation of these pathways fosters cell cycle, prevents apoptosis and leads to cytoskeleton changes in reproductive as well as non-reproductive cells. The role of Src activation in the androgen proliferative action has been recently corroborated by findings showing that specific interference in Src/AR association by synthetic peptide impairs prostate cancer cell growth in mouse model of tumorigenesis. Furthermore, androgen activation of signalling pathways controls cell migration and wound healing in fibroblasts. These findings may account for the role of AR in promoting tissue remodelling as well as cell spreading and metastasis. Examples of the functions of signalling pathways in androgen action will be here presented.
Volume 22
Article tools
My recent searches
My recently viewed abstracts
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more