ECE2010 Poster Presentations Thyroid (122 abstracts)
Parvovirus B19 infection: a possible role in autoimmune thyroid diseases
Etienne Justinien 1 , Christine Pannier 2 , Cyril Page 3 , Christine Segard 2 , Vladimir Strunski 3 , Henri Sevestre 4 , Gilles Duverlie 2 & Rachel Desailloud 1
1Endocrinology Unit, University Hospital, Amiens, France; 2Virology Unit, University Hospital, Amiens, France; 3Oto-Rhinolaryngology Unit, University Hospital, Amiens, France; 4Pathology Unit, University Hospital, Amiens, France.
Introduction: Autoimmune thyroid disease (AITD) is a common disease. It arise due to interactions between genetic background and environmental factors. However this interactions remain unclear. As it induces other autoimmune diseases, parvovirus is an attractive candidate.
Objective: To investigate the presence of parvoviral DNA in postoperative thyroid tissues.
Materials and methods: We collect prospectively postoperative thyroid specimens and serum samples from 90 patients. We investigate presence of IgG antibodies on serum samples (IgG Parvovirus B19 – Biotrin). Presence of parvoviral genome sequences in thyroid was investigated by real-time PCR (Artus* ParvoB19 TM PCR Kit – Qiagen) in serum samples and in thyroid specimens of patients, who were IgG positive (which prove a contact with parvovirus).
Results: Thirty-three patients were IgG positive. Parvoviral DNA detection was positive in 6 out of the 33 thyroid specimens. Only 1 serum sample was DNA positive out of these 6 patients. Final diagnosis was Grave’s disease in 3 out of 6 ‘DNA parvoviral positive’patients (50%) and in 3 out of 27 ‘DNA parvoviral negative’ patients (11.1%) (P=0.08). Lymphocytic infiltration was observed in 5 out of the 6 ‘DNA parvoviral positive’ patients (83.3%) and in 9 out of the 27 ‘DNA parvoviral negative’patients (33.3%) (P=0.08). Two serum samples were DNA positive out of these 27 patients.
Conclusion: DNA parvoviral presence in thyroid tissue is observed and is not due to viremia. This study suggests a possible relation between Grave’s disease, thyroid lymphocytic infiltration and parvovirus infection. Further study are needed to confirm these results.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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