Endocrine Abstracts

Objective: To determine the peculiarity of melatonin (M) at women with polycystic ovary syndrome (PCOS).

Methods: Fifty-six women with PCOS from 18 to 29 years old have been included in research. Control group 22 healthy women with regular menses, same age. Levels M were determined in the blood at 2 and 8 o’clock in the morning on a fifth day menstrual cycle in January and July.

Results: It is established, that the level of M in winter at patients with PCOS changed from 199.9 up to 288.5 pmol/l and did not differ (P>0.05) from parameters of healthy women (199.3±10.2 pmol/l). Levels of M decrease in both groups in summer, however, the degree of this decrease was differ. So in the control group the level of M has decreased on 75% and at patients with PCOS on 62.5%. Level of M in summer at patients with PCOS was bigger (75.5±9.7 pmol/l, P<0.05) than M at control group (49.8±6.4 pmol/l). It was significant that patients with PCOS have increase level of M in the morning (75.9±5.2 vs 49.9±5.4 pmol/l, P<0.05) and decrease night peak of M (52.0±3.1 vs 78.8±5.9 pmol/l, P<0.05) compared with controls. Women with PCOS have inversion rhythm of M, that was showed up reduction (P<0.05) secretions M at night relative to levels M in the morning.

Conclusions: Seasonal rhythm secretion of melatonin at patients with PCOS is stored, however, this women have disturbance circadian rhythm of melatonin that enable to make an proposes about an important role hormone of epiphysis in formation pathology of reproductive system.