ECE2010 Poster Presentations Female reproduction (44 abstracts)
Kisspeptin levels in high risk pregnancies related to chronic diseases: insulin dependent diabetes mellitus (IDDM) and arterial hypertension (H)
Dragana Miljic 1 , Aleksandar Cetkovic 2 , Aleksandar Ljubic 2 , Michael Patterson 3 , Mohammad Ghatei 3 , Steven Bloom 3 , Marina Djurovic 1 , Mirjana Doknic 1 , Sandra Pekic 1 , Marko Stojanovic 1 & Vera Popovic 1
1Institute of Endocrinology, University Clinical Center, Belgrade, Serbia; 2Clinic for Obstetrics and Gynecology, University Clinical Center, Belgrade, Serbia; 3Department of Metabolic Medicine, Imperial College London, London, UK.
Objective: Kisspeptin is hormone involved in the initiation and maintenance of fertility. Placenta is the major source of kisspeptin but its role during gestation is still matter of debate. Studies investigating kisspeptin levels during gestation in patients with diabetes and hypertension are lacking. Our aim was to prospectively evaluate kisspeptin levels in pregnant women with chronic diseases such as IDDM and H.
Design and methods: Kisspeptin levels were evaluated in 61 singleton pregnancies (16 with IDDM, 20 with H and in 25 healthy pregnant women). Blood samples were collected in the 1st trimester (9–12 weeks), in the 2nd trimester (21–25 weeks) and in the 3rd trimester (32–36 weeks). Maternal kisspeptin levels were correlated with pregnancy outcome.
Results: In pregnant women with diabetes and hypertension mean plasma kisspeptin levels were significantly lower compared to control group throughout gestation. In five pregnancies which ended in spontaneous abortion in the 2nd trimester (four in patients with diabetes and one in patient with hypertension) plasma kisspeptin levels were severely decreased in early pregnancy compared to control group. No other adverse outcomes were recorded in patients with diabetes and hypertension nor in healthy pregnant women in the study. ROC curve analysis of kisspeptin levels in the 1st trimester showed cut-off value of 812.4 pmol/l as discriminating between positive and negative pregnancy outcome (Sn=76.4% and Sp=75%).
Conclusions: Kisspeptin levels are significantly lower throughout pregnancy in women with IDDM and H. Severely decreased kisspeptin levels, in these patients, during early pregnancy may be associated with an increased risk of spontaneous abortion. Larger studies are needed to investigate the role of kisspeptin in high risk pregnancies related to various pathologies.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more