ECE2010 Poster Presentations Clinical case reports and clinical practice (80 abstracts)
Ganglioneuroblastoma: a rare cause of adrenal mass in adults
Gulsah Elbuken 1 , Zuleyha Karaca 1 , Ilkay Cakir 1 , Fatih Tanriverdi 1 , Mustafa Gulec 2 , Alper Akcan 3 , Hulya Akgun 1 , Kursad Unluhizarci 1 & Fahrettin Kelestimur 1
1Erciyes University Medical School Department of Endocrinology, Kayseri, Turkey; 2Erciyes University Medical School Department of Radiology, Kayseri, Turkey; 3Erciyes University Medical School Department of General Surgery, Kayseri, Turkey; 4Erciyes University Medical School Department of Pathology, Kayseri, Turkey.
Introduction: Neurogenic tumors in abdomen arise from ganglion cell origin and usually seen in the distribution of the sympathetic ganglia along paraspinal areas or adrenal medulla or the organ of Zuckerkandl.
Ganglioneuroblastomas are the tumors of sympathetic cell origin which have the features of both malignant and benign neuroblastoma. The presence of immature tissue indicates potentially a malignant behavior. Ganglioneuroblastomas are most often seen in the earlier ages of childhood, especially 2 to 4 years with similar frequency in boys and girls. It is extremely rare in adults. Because of this, the radiographic and pathological features of the tumor have not been clearly understood.
Case: A 29-year-old man with adrenal mass is presented. Laboratory evaluation was compatible with a non-functioning adenoma. The computed tomography revealed a well-circumscribed tumor with central hypodens area which was 3.5× 4.5 cm in size and had 38 Hounsfield unit (HU). Based on the non-benign radiological features of adrenal mass, it was removed laparoscopically. The lesion was diagnosed as ganglioneuroblastoma with adrenal gland and surrounding fatty tissue invasion.
Conclusion: The predictive value of CT and MRI characteristics of adrenal incidentalomas is quite consistent with histopathologic findings. To exclude malignancy, adrenal masses with suspicious imaging should be removed. Ganglioneuroblastoma should be kept in mind in differential diagnosis of adrenal masses with increased HU on adrenal CT.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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