ea0022eje1 | The European Journal of Endocrinology Prize Lecture | ECE2010
Hofbauer Lorenz C
Osteoclasts are derived from macrophagic/monocytic lineage cells and represent differentiated, multinucleated cells specialized in resorbing bone. An increased number and activity of osteoclasts is the hallmark of various bone diseases, including osteoporosis, rheumatoid arthritis, and skeletal metastases. Recently, receptor activator of nuclear factor-κB ligand (RANKL) has been identified as the stem cell factor for osteoclasts. RANKL promotes osteoclast formation, funct...