ECE2010 Poster Presentations Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) (125 abstracts)
Impact of rosiglitazone on serum IGF1 concentrations in uncontrolled acromegalic patients under conventional medical therapy: results from a pilot phase 2 study
Martina Lombardi 1 , Giuseppe Rossi 2 , Francesco Raggi 1 , Claudio Urbani 1 , Chiara Sardella 1 , Chiara Cosci 1 , Enio Martino 1 & Fausto Bogazzi 1
1Department of Endocrinology and Metabolism, University of Pisa, Pisa, Italy; 2Epidemiology and Biostatistics Unit, Institute of Clinical Physiology, National Research Council, Pisa, Italy.
Current therapies for acromegaly are unsatisfactory for some patients. High dose thiazoledinedines have been reported to shrink tumor size and reduce serum GH levels in animal models of acromegaly. To study the effects of increasing doses of rosiglitazone on serum GH and IGF1 concentrations in acromegalic patients, we designed a phase two clinical trial. We enrolled five consecutive patients with active acromegaly uncontrolled under conventional therapies. They received increasing doses of rosiglitazone (4 mg each month starting from 8 mg up to 20 mg/day), added to previous therapies for acromegaly. Mean serum IGF1 concentrations reduced from 547±91 to 265±126 μg /l (P=0.043) during the 4 months-course with rosiglitazone; main reduction occurred with the higher dose of rosiglitazone; on the opposite, lower doses of rosiglitazone left serum IGF1 levels unaffected in 4/5 patients. IGF1 normalized in all patients. Serum GH concentrations did not significantly changed as well as all other pituitary hormones. No main side-effects were observed. Studies in Hep G2 cells showed that rosiglitazone reduced hepatic GH-dependent generation of IGF1. Conclusion: Rosiglitazone reduces serum IGF1 concentrations in patients with active acromegaly, likely acting on the GH-dependent hepatic synthesis of IGF1. Large studies are necessary to confirm whether rosiglitazone may have a role as a new adjuvant therapy for acromegalic patients.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more