Endocrine Abstracts

We examined 56 normoprolactinemic women of reproductive age (18–45 y.o.) with isolated hypogonadotropic hypogonadism (group 1) initially and on treatment with 2 mg of 17β-estradiol and 10 mg of dydrogesterone in sequenced manner (HRT), duration of HRT was from 18 to 42 (median 36) months; 45 healthy women (20–38 y.o.) were included in control group 2.

Initially hypercholesterolemia was observed in 50% of cases in group 1 and 6.6% in group 2 (z=12.29 P=0.0005); nevertheless, the difference in lipid levels between groups 1 and 2 was not statistically significant: total cholesterol levels 5.2 (4.3; 6.0) mmol/l and 4.63 (4.15; 5.15) mmol/l respectively (1 vs 2 P=0.1); triglycerides 0.8 (0.62; 1.3) mmol/l and 0.76 (0.6; 0.85) mmol/l (1 vs 2 P=0.08); HDL 1.89 (1.24; 2.1) mmol/l and 1.79 (1.44; 2.8) mmol/l (1 vs 2 P=0.85); LDL 2.7 (2.2; 3.2) mmol/l and 2.75 (2.3; 3.3) mmol/l (1 vs 2 P=0.64). In group 1 decrease of total cholesterol and triglycerides concentrations was found on HRT: total cholesterol 4.8 (3.95; 5.1) mmol/l (before versus on treatment P=0.041), triglycerides 0.65 (0.6; 0.9) (before versus on treatment p=0.044) respectively, changes in HDL and LDL levels were not revealed.

Initial concentrations of Ca⁺⁺, P, and alkaline phosphatase (AP) were within normal range in all women. However, concentrations of Ca⁺⁺ and AP were higher in group 1 compared to group 2: Ca⁺⁺ 1.13 (1.08; 1.19) mmol/l and 1.05 (1.03; 1.09) mmol/l (1 vs 2 P=0.0016); AP 161.5 (141.8; 183) IU/l and 141.0 (119; 151) IU/l (1 vs 2 P=0.044). On HRT reduce in Ca⁺⁺ and AP concentrations was observed: Ca⁺⁺ concentrations 1.05 (1.03; 1.10) mmol/l (before versus on treatment P=0.004), AP 139 (112; 143) IU/l (before versus on treatment P=0.004).

Thus, despite lacking the expressed biochemical disorders, isolated hypogonadotropic hypogonadism in women of reproductive age have hidden impact on lipid and mineral metabolism. HRT significantly improved parameters of lipid and mineral homeostasis in this cohort of patients.