ECE2010 Poster Presentations Female reproduction (44 abstracts)
The effect of hormone therapy and tibolone on serum CD40L and ADAM-8 in healthy postmenopausal women
Irene Lambrinoudaki 1 , Maria Karaflou 1 , George Kaparos 2 , Odysseas Grigoriou 1 , Andreas Alexandrou 3 , Constantinos Panoulis 1 , Emanuel Logothetis 2 , Maria Creatsa 1 , George Christodoulakos 1 & Evangelia Kouskouni 2
1Second Department of Obstetrics and Gynecology, School of Medicine, Aretaieio Hospital, Athens University, Athens, Greece; 2Hormonal and Biochemical Laboratory, School of Medicine, Aretaieio Hospital, Athens University, Athens, Greece; 3First Department of Surgery, School of Medicine, Laiko Hospital, Athens University, Athens, Greece.
Background/aim: The role of neutrophils and platelets in atherothrombotic disease is well established. The aim of our study was to investigate the effect of hormone therapy and tibolone on the soluble markers of neutrophil and platelet activation, ADAM-8 and CD40L respectively, in healthy postmenopausal women.
Subjects and methods: One hundred and six healthy postmenopausal women were randomly allocated to: estradiol plus drospirenone (E2/DSP), estradiol hemihydrate 1 mg plus norethisterone acetate (E2/NETA) 0.5 mg and tibolone 2.5 mg. Serum ADAM-8 and CD40L were measured at baseline and at 6 months.
Results: Baseline values of ADAM-8 and CD40L were similar between groups. No significant changes were observed between baseline values and values at 6 months.
Conclusions: No association has been revealed between estrogen plus progestin treatment or tibolone on serum ADAM-8 and CD40L levels in healthy postmenopausal women. Larger prospective studies are needed to further investigate the effect of low-dose hormone therapy or tibolone on serum markers of neutrophil and platelet activation.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more