Searchable abstracts of presentations at key conferences in endocrinology

Endocrine Abstracts

Published by BioScientifica

P461

Prev Next
Section Contents Cite
Endocrine Abstracts (2010) 22 P461

ECE2010 Poster Presentations Female reproduction (44 abstracts)

Estrogen plus progestin treatment: effect of different progestin components on serum markers of apoptosis in healthy postmenopausal women

Maria Karaflou 1 , George Kaparos 2 , Demetrios Rizos 2 , Emanuel Logothetis 1 , Andreas Alexandrou 3 , Leon Aravantinos 1 , Maria Creatsa 1 , George Christodoulakos 1 , Irene Lambrinoudaki 1 & Evangelia Kouskouni 1

0
Err

1Second Department of Obstetrics and Gynecology, School of Medicine, Aretaieio Hospital, University of Athens, Athens, Greece; 2Hormonal and Biochemical Laboratory, School of Medicine, Aretaieio Hospital, University of Athens, Athens, Greece; 3First Department of Surgery, School of Medicine, Laiko Hospital, University of Athens, Athens, Greece.

Objective: To investigate the effect of two hormone therapy (HT) regimens differing only in their progestin component on serum markers of apoptosis.

Design: Randomized, double-blinded study.

Patients: One hundred healthy postmenopausal women.

Interventions: Patients were randomized to 17β-estradiol 1 mg/drosperinone 2 mg (E2/DSP) or 17β-estradiol 1 mg/norethisterone acetate 0.5 mg (E2/NETA) for 6 months.

Main outcome measures: Serum soluble Fas (sFas), soluble Fas Ligand (sFasL) and cytochrome-c (cyt-c) at baseline and at 6 months.

Results: Serum sFas and serum sFasL significantly decreased in both groups. Serum cyt-c in both groups was undetectable. sFas/sFasL ratios were reduced in both groups.

Conclusions: sFas/sFasL ratios decreased in both groups suggesting a decrease in apoptosis associated with the above pathway. cyt-c levels were undetectable, suggesting an absence of mitochondria-associated apoptosis.

Volume 22

Prev Next

12th European Congress of Endocrinology

European Society of Endocrinology 

Browse other volumes

Summary Programme Volume Editors Abstracts

Article tools

| Disclaimer

My recent searches

No recent searches.

My recently viewed abstracts

Estrogen plus progestin treatment: effect of different progestin components on serum markers of apoptosis in healthy postmenopausal women (<1 min ago)

Authors

Published by BioScientifica

Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 | Privacy policy | Cookie settings

BiosciAbstracts

Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.

Find out more