Endocrine Abstracts

Introduction: High total cholesterol (tChol), LDL and trygliceride (TAG) level is independent risk factor for cardiovascular disease. High prevalence of malignant atherogenic profile is alarming in type 2 diabetics (high triglyceride, low HDL). It is very often that dislipidemia is associated with diabetes and obesity, as well as hypertension.

Aim: The aim of this study is to analyse lipid profile in patients with type 2 diabetes in Kragujevac depending on gender and therapy of diabetes.

Materials and methods: This study included all patients registered in Primary Care with type 2 diabetes. We determinated lipid profile: tChol, LDL, HDL and TAG. Patients were divided according to therapy in 2 groups: oral agents and insulin therapy.

Results: We registered 3108 patients with type 2 diabetes in Kragujevac. Anamnestic, previous lipid disorder had 23.5%. According to National guideline clinical practise criteria: 83.3% had increased tChol level, 69.9% increased LDL, 55.2% increased TAG i 76.8% decreased HDL cholesterol level. There is statisticaly significance in average tChol level (men versus women): (5.7±1.19 vs 6.09±1.17 mM, P<0.001), as well as LDL (3.39±0.87 vs 3.66±1.04 mM, P<0.001), but there is no significance in TAG (2.26±1.76 vs 2.17±1.3 mM, P=0.378) and HDL (1.41±0.37 vs 1.47±0.34 mM, P=0.06). There is statisticaly higher average HDL in patients with oral antidiabetics than in patients with insulin therapy (1.46±0.34 vs 1.36±0.36 mM, P=0.006), but there is no significance inaverage LDL (3.57±0.99 vs 3.53±1.02 mM, P=0.699), tHol (5.98±1.2 vs 5.86±1.15 mM, P=0.278) and TAG (2.23±1.5 vs 2.06±1.29 mM, P=0.209) depending on therapy of diabetes.

Conclusion: The prevalence of lipid disorders in type 2 diabetics is high. There is statistically significantly higher tHOL and LDL in women. Patients with oral therapy have statistically higher values HDL than patients on insulin therapy. This values showed not satisfied liporegulation in type 2 diabetics.