ECE2010 Poster Presentations Cardiovascular endocrinology and lipid metabolism (48 abstracts)
Alterations of plasminogen activator inhibitor-1, myeloperoxidase and matrix metalloproteinase-9 in coronary artery disease patients with type-2 diabetes mellitus
Peteris Tretjakovs 1, , Antra Jurka 1, , Inga Bormane 1 , Guntis Bahs 1, , Kristine Cirule 3 , Agris Martinsons 1 , Jurijs Verbovenko 1, & Valdis Pirags 1,
1University of Latvia, Riga, Latvia; 2Pauls Stradins Clinical University Hospital, Riga, Latvia; 3Riga Stradins University, Riga, Latvia.
Aim: To evaluate alterations in plasminogen activator inhibitor-1 (PAI-1), myeloperoxidase (MPO) and matrix metalloproteinase-9 (MMP-9) levels, and their relation to insulin resistance (IR) in coronary artery disease (CAD) patients with stable and unstable angina with and without type-2 diabetes mellitus (T2DM).
Patients and methods: CAD patients were recruited into four groups: 16 CAD patients with stable angina and T2DM (SD); 16 CAD patients with stable angina, without T2DM (S); 16 CAD patients with unstable angina and T2DM (UD); and 16 CAD patients with unstable angina, without T2DM (U). 16 healthy subjects were selected as controls (C). The study groups were matched for age and sex. IR was measured by HOMA-IR method. Serum PAI-1 (total), MPO and MMP-9 were determined by xMAP technology (Luminex-200 analyzer).
Results: All patient groups demonstrated a significant increase in PAI-1, MPO and MMP-9 levels (P<0.05) and IR (P<0.05). The increase of PAI-1, MPO and MMP-9 was more pronounced in UD and U groups compared to SD and S groups (P<0.05), but the IR elevation was more pronounced in both diabetics groups (UD and SD). Only the concentration of PAI-1 and MMP-9 correlated with IR (P<0.05).
Conclusion: Our findings show that CAD patients independently of 2TDM have elevated IR, besides CAD patients with unstable angina have higher levels of PAI-1, MPO and MMP-9 than patients with stable angina.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more