ECE2010 Poster Presentations Cardiovascular endocrinology and lipid metabolism (48 abstracts)
Searching for the metabolic syndrome criteria in young adults with hypogonadism
Alper Sonmez 1 , Cem Haymana 2 , Erol Bolu 1 , Serkan Tapan 3 , Cem Barcin 4 , Aydogan Aydogdu 1 , Abdullah Taslipinar 1 & Mustafa Kutlu 1
1Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara, Turkey; 2Department of Internal Medicine, Gulhane School of Medicine, Ankara, Turkey; 3Department of Biochemistry, Gulhane School of Medicine, Ankara, Turkey; 4Department of Cardiology, Gulhane School of Medicine, Ankara, Turkey.
Introduction: The evidence shows that the prevalence of metabolic syndrome is increased in patients with hypogonadism. However, much of the data regarding this association comes from the elderly patients with obesity, hypertension or type 2 diabetes. The total testosterone levels alter physiologically in these conditions and thus can falsify the association. We aimed to investigate the prevalence of the metabolic syndrome in young adults with hypogonadism who do not have any confounders.
Methods: A retrospective design was performed. The demographic data and the laboratory values of the 318 hypogonad men (age: 21.68±2.09 years, BMI: 21.93±3.1 kg/m2) were compared with those of 1089 healthy volunteers matched for age (21.39±1.49 years) and BMI (22.04±1.6 kg/m2).
Results: The patients had higher waist circumferences, systolic and diastolic blood pressures, triglycerides (P<0.001 for all), total cholesterol (P=0.02), LDL cholesterol (P=0.03) and lower HDL cholesterol levels (P=0.001) than the controls. Blood glucose levels of the two groups were similar.
Conclusion: Although the waist circumferences, blood pressures and lipid profiles of the young adults with hypogonadism do not fulfill the metabolic syndrome criteria, they are significantly different from those of the healthy young adults. Whether this profile poses an increased cardiovascular risk in this population, merits further investigation.
| Patients (n=318) | Control (n=1089) | P | |
| Waist circumference (cm) | 81.60±10.7 | 77.06±5.2 | <0.001 |
| Arterial BP (mmHg) | 114.18±11.2/ 73.68±8.5 | 107.66±11.2/ 68.02±9.58 | <0.001 |
| HDL-Chol. (mg/dl) | 45.23±10.6 | 47.27±9.39 | 0.001 |
| Triglyceride (mg/dl) | 102.30±48.7 | 82.66±29.9 | <0.001 |
| Fasting glucose (mg/dl) | 85.60±7.97 | 85.78±7.04 | 0.74 |
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Endocrine Abstracts
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