Gender variations of serum Paraoxonase-1 activities in healthy young men and women: association with carotid intimae media thickness

Dilek Gogas Yavuz; Ozlem Tarcin; Palmet Gun; Onder Sirikci; Sema Akalin

P147

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Endocrine Abstracts (2010) 22 P147

ECE2010 Poster Presentations Cardiovascular endocrinology and lipid metabolism (48 abstracts)

Gender variations of serum Paraoxonase-1 activities in healthy young men and women: association with carotid intimae media thickness

Dilek Gogas Yavuz , Ozlem Tarcin , Palmet Gun , Onder Sirikci & Sema Akalin

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Marmara University School of Medicine, Istanbul, Turkey.

Aim: Paraoxonase-1 (PON-1), an HDL-associated enzyme has been shown to possess antioxidant properties that protect against atherosclerosis. The aim of this study is to evaluate serum paraoxanase activities, lipid profiles and carotid intimae media thickness (CIMT) as an early marker of atherosclerosis in healthy man and women.

Method: Four hundred healthy volunteers (F/M: 250/150, 19–23 years) included in the study. Serum paraoxonase and arylesterase activities, lipids and Apo a levels were measured. CIMTwas evaluated with Doppler ultrasonography.

Results: Biochemical parameters are shown at the Table 1.

Table1 Biochemical parameters of the study groups.
	Women (n:250)	Men (n:150)	P
Paraoxonase activity (U/l)	239.4	266.6	0.08
Arylesterase activity (U/l)	90 287	102 757	0.008
Triglyceride (mg(dl)	59.6	85.9	<0.0001
HDL (mg/dl)	58.5	47.3	<0.0001
LDL (mg/dl)	84.4	94.4	0.0002
VLDL (mg/dl)	11.9	16.2	<0.0001
Apo a (g/l)	1.38	1.17	<0.0001

CIMT measurement was significantly higher in man (0.460±0.02 cm) compared to women (0.450±0.02 cm, P=0.006). Body mass index was lower in women (20.8±3.4 kg/m²) than man (23.5±4.1 kg/m²) (P<0.001). Serum paraoxonase activity was positively correlated with arylesterase (r=0.31, P<0.001) and HDL levels (r=0.14, P=0.03), negatively correlated with CIMT (r=−16, P=0.03) in women. Arylesterase activity was positively correlated with HDL levels (r=0.14, P=0.04) in women. In men paraoxonase activity showed significant correlation with arylesterase activity (r=0.20, P<0.01) but not with CIMT.

Conclusion: A Serum PON-1 activity varies between young man and women. PON-1 activities against different substrates and mass of the enzyme need to be studied for antioxidant properties of PON-1 enzyme.