ECE2010 Poster Presentations Cardiovascular endocrinology and lipid metabolism (48 abstracts)
Ligands of receptor for advanced glycation end-products in stable coronary artery disease: their potential contribution to atherogenesis exceeds beyond diabetes mellitus
Justyna Kuliczkowska-Plaksej 1 , Wlodzimierz Bednorz 1 , Grazyna Bednarek-Tupikowska 1 , Rafal Plaksej 2 , Roksolana Derzhko 2 , Adam Spring 2 & Andrzej Milewicz 1
1Department of Endocrinology, Diabetology and Isotope Treatment, Wroclaw Medical University, Wroclaw, Poland; 2Department of Cardiology, Wroclaw Medical University, Wroclaw, Poland.
Receptor for advanced glycation end-products (RAGE) signalling, crucial for diabetic macroangiopathy, is also highly suspected to be involved in atherogenesis in the setting of preserved glucose metabolism.
Aim: To determine the relationships between peripheral blood concentrations of RAGE agonists, namely amfoterin (HMBG1) and carboxy-methylo-lisine (CML) as well as RAGE inhibitor Endogenously Secretory RAGE (esRAGE), and the severity of atherosclerosis in coronary arteries in patients (pts) with stable coronary artery disease (CAD).
Methods: A total of 84 pts aged 56±9.2 years (43 males, 30 pts with diabetes mellitus /DM/) were classified as one-, two- or three-vessel CAD (n=32, n=31 and n=21, respectively) based on coronary angiography. Atherosclerotic lesions were also evaluated according to Sullivan’s score. HMBG1, CML and esRAGE were measured using ELISA tests. The control group comprised 43 healthy counterparts.
| 1-,2-,3-vessel CAD; R2=0.44 | Stenosis score; R2=0.46 | Extend score; R2=0.59 | |
| Male gender | 0.19; P<0.01 | NS | 0.27; P<0.001 |
| Hypertension | 0.27; P<0.001 | 0.21; P<0.01 | 0.16; P<0.02 |
| DM | NS | NS | 0.15; P<0.03 |
| HMBG1 | 0.39; P<0.0001 | 0.51; P<0.0001 | 0.44; P<0.0001 |
| esRAGE | NS | −0.26; P<0.001 | NS |
| NS, non significant | |||
Results: The levels of HMBG1 and CML were higher (P<0.05 and P<0.01, respectively) and esRAGE was lower (P<0.001) in CAD pts than in the controls. In multivariate analyses, HMBG1 and esRAGE were among independent correlates of parameters describing the severity of coronary atherosclerosis regardless the presence of DM (Table).
Conclusions: In pts with stable CAD (1) RAGE ligands concentrations are altered and (2) significantly associated with the extension of coronary atherosclerosis, thus underlining the notion of RAGE axis contributing to atherogenesis in general population.
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Endocrine Abstracts
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