Endocrine Abstracts

The central role of GnRH in gonadotropin was established over four decades ago. The development of agonist and antagonist analogs and the understanding of its interaction with the GnRH receptor has revolutionized the treatment of hormone-dependent diseases and controlled induction of ovulation for IVF.The absence of steroid and metabolic product receptors in GnRH neurons has presented a conundrum for understanding feedback and mechanisms for gonadotropin...