Endocrine Abstracts

Context: Serum calcitonin (hCT) measurement may be useful for detecting medullary carcinoma (MTC), but the routine use of hCT and after pentagastrin stimulation to screen patients with nodular thyroid disease remains controversial.Patients: One thousand and seven patients (667 females, 440 males) with nodular thyroid disease and a mean age of 55±14 (mean±S.D.) years were included in the study. All patients did not have impaired r...

We have recently demonstrated induction of tumor-selective accumulation and therapeutic efficacy of radioiodine in neuroblastoma tumors after systemic non-viral polyplex-mediated sodium-iodide-symporter (NIS) gene delivery.In the current study, we evaluated the efficacy of novel synthetic nanoparticle vectors based on linear polyethylenimine (LPEI), shielded by polyethylene glycol (PEG), and coupled with the synthetic peptide GE11 as an epidermal growth ...

Many studies demonstrated that somatic BRAF gene mutation analysis increases diagnostic accuracy for papillary thyroid carcinoma (PTC), even from very small samples. The gold standard for point mutations research is direct sequencing, that implies DNA extraction, PCR with specific primers, sequencing reaction and run on an automatic sequencer. This is an expensive and time consuming method, and the possible contamination with wild-type DNA not coming from the nodule significan...

Aim: Patients with autoimmune thyroid disease (AITD) or type 1 diabetes (T1DM) are prone to develop other autoimmune diseases. This has led to the concept of autoimmune polyglandular syndromes (APS). It has been proposed that AITD and type 1 diabetes are both part of the same APS (subtype 2). This would imply that they associate with the same diseases. We evaluated whether the clustering of autoimmune antibodies differs between AITD and T1DM.Methods: Ant...

Objective: Thyroid dysfunctions have various effects on glucose and lipid metabolism. Adiponectin (ADP) is an adipokine decreased in obesity and insulin resistance. In this study, we aimed to investigate the role for ADP in thyroid dysfunction related changes in glucose and lipid metabolism.Methods: Newly diagnosed overt hypothyroid (n=20) and thyrotoxic (n=23) adult patients with a body mass index (BMI)<30 kg/m2 were include...

Aim of the study: To evaluate efficacy and safety of ultrasound-guided percutaneous laser ablation (PLA) on benign thyroid nodule size reduction, thyroid function and autoimmunity.Methodology: This study was approved by local institutional review committee. All data are mean±S.D. Two hundred and ninety-eight euthyroid outpatients (F=241, M=57; age 50.7±12.0 years) with a benign thyroid nodule (volume 23.1±21.3 ml) causing ei...