Endocrine Abstracts

Mitotane therapy is associated with many side effects, including thyroid function perturbations mimicking central hypothyroidism, possibly due to laboratory test interference or pituitary direct effects of mitotane. Therefore, we aimed at investigating whether increasing concentrations of mitotane in the therapeutic range might interfere with thyroid hormone assays and evaluate the effects of mitotane on a mouse TSH- producing pituitary cell line. TSH, FT4 and FT<su...

Introduction: Subclinical hyperthyroidism (SH) affects about 1% of population. The diagnosis of this disease leans on the laboratory criteria only: decreased of TSH and normal FT3 and FT4 levels. SH increases mortality mostly due to cardiovascular diseases including arrhythmia and overload of the heart. Enlarging of heart chambers is one of the cause of arrhythmia, and cardiac index is one of indicators of heart after load.Aim: To e...

In Turner persons questionnaire surveys have identified quality of life, perception of health and education to be at a similar or higher level compared to the background population. To shed further light on these seemingly paradoxical findings in Turner persons we aimed to analyze various socio-economic parameters in Turner persons compared to an age-matched female background population.All diagnosed Turner syndrome women nationwide (n=977) were i...

Objective: The LH and chorionic gonadotropin (CG) are essential for reproduction and male sexual development. While LH induces tesosterone production, CG is essential for the establishment of pregnancy. In the New World Monkeys (NWM) the initial duplication of the ancestral LH-beta subunit (LHB) gene, which gave rise to the novel CG-beta subunit (CGB) gene, was followed by a genomic rearrangement event, leading to CGB expression in pituitary and placenta, whereas LHB became a ...

Objective: Premature ovarian failure (POF) is not an early menopause and intermittent ovarian function can be spontaneously observed in POF patients. We sought to characterize these patients and determine which factors were predictors of intermittent ovarian function.Patients and methods: Among 391 patients with idiopathic POF followed from 1997 in our department, 67 (17.1%) patients (Group 1) had POF fluctuating criteria: FSH <15 IU/l, resumed spont...

Screening of thyroid disorders in pregnancy has been a matter of controversy. Recent recommendations favour targeted high-risk case finding though this approach may miss a significant number of those affected (Vaidya et al. JCEM 2007).Among 398 non-selected women in the 10th week of pregnancy, thyrotropin (IRMA) >3.5 mIU/l was found in 10.3%, free thyroxine (RIA) <10 pmol/l in 2% and thyroperoxidase antibodies (RIA) >50 IU/ml in...