SFEBES2009 Poster Presentations Bone (25 abstracts)
The association among bone mineral density (BMD), 24-h mean sex hormone binding globulin (SHBG) concentration and its circadian rhythm
Aung Mon 1 , Franklin Joseph 3 , Anna Robinson 2 , Ashwin Joshi 1 , Nagaraj Malipatil 1 , Rabia Aftab 2 , William Fraser 1, & Jiten Vora 1,
1Royal Liverpool University Hospital, Liverpool, UK; 2Unversity of Liverpool, Liverpool, UK; 3Countess of Chester Hospital, Chester, UK.
Introduction: The role of hormones and their underlying mechanisms in the development of osteoporosis are complex and not completely understood. Serum SHBG concentration is increased in older men and may be correlated with reduced bone mineral density and increased fracture risk. However, there is little data on exact relation of BMD with 24-h mean concentration and circadian rhythm of SHBG.
Methods: We measured 24-h mean SHBG concentration in 3 groups of volunteers matched for body mass indices: six healthy young men with normal BMD (HYM) (mean age – 27.4±4.6 years), eight older men with normal BMD (NBMD) (mean age – 70.5±2.09 years) and ten older men with osteoporosis (OBMD) (mean age – 69.8±3.2 years). All individuals had normal serum testosterone concentrations. Circadian rhythm parameters (midline estimate statistic of rhythm (MESOR), acrophase and amplitude) were analysed using Chronolab 3.0. The differences between groups were determined using Student’s t-test for unpaired data taking into account the 49 measurements for each individual in all 3 groups.
Results: The 24-h mean SHBG concentration and MESOR in the HYM group (11.29±0.15 and 10.88±1.84 pmol/l) were significantly lower than in the NBMD group (13.83±0.21 and 15.15±1.88 pmol/l, P<0.001) which in turn were significantly lower than in the OBMD group (21.38±1.94 pmol/l, P<0.001). There were significant SHBG circadian rhythms in all 3 groups (acrophase-14.02, P−0.046 in the HYM group, acrophase-0.56, P−0.049 in the NBMD group and acrophase-12.28, P<0.001 in the OBMD group) with the peak at mid-day and the nadir at night: concerted circadian rhythm was observed to be more pronounced in the OBMD group. Amplitudes of HYM and NBMD groups were not significantly different (P 0.09). However, amplitude of the OBMD group was significantly higher than that of the other two groups (P<0.01).
Conclusion: Higher 24-h SHBG concentration and alteration of its circadian rhythm are possible etiologic factors in development of osteoporosis in elderly men.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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