ECE2009 Poster Presentations Reproduction (50 abstracts)
Is there a need for withdrawal test with oral micronized natural progesterone in the evaluation of women with polycystic ovary syndrome?
Sarantis Livadas , Georgios Boutzios , Frangiskos Economou , Krystallenia Alexandraki , Xenofon Xyrafis , Aristea Zerva , Athanasios Karachalios & Evanthia Diamanti-Kandarakis
Endocrine Section, First Department of Medicine, University of Athens Medical School, Athens, Greece.
Objective: To investigate the effects of oral natural micronized progesterone on hormonal and metabolic parameters in patients with polycystic ovary syndrome (PCOS) and to answer the clinical question if induction of withdrawal bleeding is a necessity for the comparison of hormonal and metabolic data in PCOS subjects.
Design: Prospective clinical study.
Setting: Academic medical centre.
Population: Twenty eight reproductive-aged women with PCOS.
Main outcome measures: Blood sampling was collected at baseline, following 7 days of oral natural micronized progesterone (200 mg) administration and post withdrawal bleeding. At these three stages hormonal parameters and HOMA-IR index were assessed in all patients.
Results: Oral natural micronized progesterone administration did not alter significantly insulin sensitivity index and androgen levels; however LH was decreased when post bleeding values were compared to baseline. Nevertheless, following oral natural micronized progesterone administration,progesterone and 17OH-progesterone concentrations were raised, and HOMA-IR was lowered, whereas androgens levels were not altered, in comparison to baseline.
Conclusions: The induction of withdrawal bleeding, with this regimen, does not appear to be a necessity for the assessment of hormonal and metabolic profile in anovulatory women with PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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