ECE2009 Poster Presentations Reproduction (50 abstracts)
A systematic review and a meta-analysis on adiponectin levels in women with polycystic ovary syndrome
Konstantinos Toulis 1, , Dimitrios Goulis 1, , Dimitrios Farmakiotis 1, , Ilias Katsikis 1, , Neoklis Georgopoulos 1, , Basil Tarlatzis 1, , Ioannis Papadimas 1, & Dimitrios Panidis 1,
1Aristotle University, Thessaloniki, Greece; 2Medical School, Patra, Greece.
Background: Conflicting results regarding adiponectin levels in women with polycystic ovary syndrome (PCOS) have been reported. To evaluate adiponectin levels in PCOS, a systematic review of all studies comparing adiponectin levels in women with PCOS to healthy controls and a meta-analysis of those involving women with similar Body Mass Index (BMI) were performed. Influence of possible effect modifiers, such as insulin resistance (IR) and testosterone, was investigated. Influence of obesity was investigated through a ‘nested’ meta-analysis after within-study BMI stratification and appropriate pooling.
Methods: Literature search was conducted independently through MEDLINE, EMBASE, Cochrane CENTRAL (through June 2008), references from relevant studies and personal contact with the authors. Thirty-one studies, reporting data on 3469 subjects, were reviewed and sixteen included in the meta-analysis.
Results: Women with PCOS demonstrated significantly lower adiponectin values (Weighted Mean Difference (95% CI) –1.71 (−2.82 to −0.6), P<10−4), yet with significant between-study heterogeneity. In larger studies and in studies with modest difference in IR between PCOS and control groups, no significant difference in adiponectin was observed. IR was the only significant covariate in the univariate meta-regression model. Data on high molecular weight (HMW) adiponectin is limited (three studies).
Conclusions: After controlling for BMI-related effects, adiponectin levels seem to be lower in women with PCOS compared to non-PCOS controls. Hypoadiponectinaemia was present in both lean and obese women with PCOS when compared with non-PCOS counterparts. Low levels of adiponectin in PCOS are probably related to IR but not to testosterone. Further investigation is needed for HMW adiponectin levels in PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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