ECE2009 Poster Presentations Reproduction (50 abstracts)
Advanced glycosylated end products are associated with anovulatory markers in women with polycystic ovary syndrome
Evanthia Diamanti-Kandarakis 1 , Athanasia Piouka 2 , Sarantis Livadas 1 , Christine Piperi 3 , Ilias Katsikis 2 , Athanasios Papavasiliou 3 & Dimitrios Panidis 2
1Endocrine Section, First Department of Medicine, University of Athens Medical School, Athens, Greece; 2Division of Endocrinology and Human Reproduction, Second Department of Obstetrics and Gynecology, Thessaloniki, Greece; 3Laboratory of Biological Chemistry, University of Athens Medical School, Athens, Greece.
Background: Chronic anovulation constitutes one of the cardinal features of Polycystic Ovary Syndrome (PCOS) and Anti-Müllerian hormone (AMH), a granulosa cell product, is a well documented marker of anovulation. Recent data have shown that oxidative stress is involved in the pathophysiology of anovulation. A marker of oxidative stress, Advanced Glycosylated End products (AGEs), is implicated to the pathogenesis of the syndrome and have been localized with high intensity in the granulosa cells of polycystic ovaries. The aim of this study was to investigate whether AMH is linked with oxidative stress markers in PCOS.
Methods: Biochemical, hormonal and ultrasonographic parameters from 37 anovulatory PCOS (PCOS-Anov) and 23 regularly ovulating PCOS (PCOS-Ov), were compared with the corresponding ones from 11 anovulatory non-PCOS women (Non-PCOS Anov) and 25 controls. All subjects were age and BMI matched.
Results: AMH values were statistically significantly higher in PCOS-Anov in comparison to PCOS-Ov and other groups (7.63±3.12 in PCOS-Anov, > 4.92±2.50 in PCOS-Ov, > 3.66±1.4 in Non-PCOS Anov > and 4.02±1.27 ng/ml in controls, P<0.001). A similar pattern of AGEs distribution values was observed (8.70±1.65 in PCOS-Anov, > 7.43±1.79 in PCOS-Ov, >5.21±0.09 in Non-PCOS Anov > and 5.85±0.89 U/ml in controls, P<0.001). Follicle number was significantly higher in PCOS-Anov in comparison to all other groups. Additionally a significant positive correlation between AMH and AGEs was observed (r:0.326, P<0.01).
Conclusions: In conclusion, the significant positive correlation between, the AGEs, an oxidative stress markerwith the stronger marker of anovulation AMH, suggest a link of oxidative status with anovulation in PCOS.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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