ECE2009 Poster Presentations Neuroendocrinology, Pituitary and Behaviour (74 abstracts)
Adiponectin and visfatin: a link with bone mineral density in acromegaly
Eugenia Resmini 1 , Nuria Sucunza 2 , M Jose Barahona 1 , Alicia Santos 1, , J Maria Fernández-Real 3 , Wilfredo Ricart 3 , J Maria Moreno 3 , José Farrerons 4 , José Rodríguez Espinosa 5 , AM Marin 4 & Susan M Webb 1
1Hospital Sant Pau, CIBER-ER Unidad 747, Endocrinology, Barcelona, Spain; 2Hospital Manacor, Mallorca, Spain; 3Hospital Josep Trueta, Girona, Spain; 4Internal Medicine, Hospital Sant Pau, Barcelona, Spain; 5Biochemistry Department, Hospital Sant Pau, Barcelona, Spain.
Two adipokines highly expressed in fat mass, adiponectin with antiinflammatory and antiatherogenic properties, and visfatin with an insulin-mimetic effect, are potential contributors to bone metabolism. In acromegaly data on adiponectin are contradictory and there are no data on visfatin.
Objectives: To evaluate adiponectin and visfatin in acromegaly, compared to control subjects and to analyze their relationship with body composition and bone mineral markers.
Methods: Bone markers (osteocalcin, amino-terminal propeptide of type 1 procollagen (P1NP), cross-laps), body composition (by DEXA), adiponectin (ELISA) and visfatin (immunoanalysis) were evaluated in 60 acromegalic patients (24 males and 36 females) and in 105 age- and gender matched healthy controls (33 males and 72 females). Acromegalic patients were classified as controlled, with normal IGF-I and GH ≤1 μg/l (n=41) or active (n=19).
Results: Acromegalic patients had lower adiponectin (P<0.01), more lean body mass (P<0.01) and total body mass (P<0.01), higher bone formation markers (osteocalcin and P1NP, P<0.05 and P<0.01 respectively), but lower bone resorption markers (cross-laps) and fat mass (both total and trunk, P<0.05) than controls (P<0.001). No differences in visfatin and bone mineral density (BMD) were found between patients and controls. Adiponectin correlated negatively with BMD (r=−0.374; P<0.05) and lean mass (r=−0.301; P<0.05) and positively with age (r=0.347; P<0.001). Visfatin correlated negatively with BMD (r=−0.359; P<0.05).
Conclusions: Acromegalic patients present hypoadiponectinemia. BMD is predictor for adiponectin and visfatin in patients with acromegaly. No correlations were found between individual bone markers and both cytokines. Adiponectin and visfatin could be a link between fat mass and bone in acromegalic patients. Supported by a grant form FIS 05/448.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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