Endocrine Abstracts

Introduction: In this study, we aimed to examine the weight alterations after the medical treatment and compare the effects of medical treatment in obese patients who applied to Endocrinology Policlinic.

Material and method: We examined the patients who were diagnosed as obesity and initiated medical treatment at Endocrinology and Metabolism Diseases Policlinic in Inonu University Medical Faculty between Agust 2005–May 2008. Patients were divided into two groups. In the first group, we applied 120 mg orlistat three times per day before each meal. In the second group, we applied 15 mg sibutramine once a day before breakfast. We evaluated the patients at the beginning and at the end of the third month of the treatment.

Inventions: Out of the total 342 patients, 172 patients were treated with orlistat and 170 patients were treated with sibutramine. The mean values of age, height, weight and BMI were similar at the initial evaluation (P>0.05). Mean values of weight, BMI of the patients at the initial and the third month controls who were treated with orlistat (group 1) and sibutramine (group 2) were demonstrated on Table 1.

There was no significant difference between two groups in means of third month values after the treatment.

Conclusion: Both of the drugs were found as effective in losing weight. There was no significant difference between these two drugs in means of weigt loss.